Auditorium at the Prinses Máxima Centre for Pediatric Oncology, Utrecht, The Netherlands on November 21st, 2022
Program
12.00 – 13.00 Walk-in and lunch
13.00 – 13.15 Welcome by PNB steering committee and Alwin Huitema (local organizer)
13.15 – 13.50 Laura Nijstad, Princess Maxima Centre for Pediatric Oncology, Utrecht & Erasmus MC, Rotterdam (NL)
Using pharmacometrics for the pharmacological dose optimization in children with cancer
13.50 – 14.15 Suzanne van der Gaag, Amsterdam UMC, Amsterdam (NL)
Physiologically based pharmacokinetic modelling of the PSMA radioligand 18F-DCFPyL to predict the tissue distribution in patients with prostate cancer
14.15 – 14.40 Mohammed Saleh, Leiden University, Leiden (NL)
The LeiCNS-PK3.0 PBPK framework to optimize CNS drug development in COVID-19 and Alzheimer’s disease
14.40 – 15.05 Amit Taneja, Galapagos, Leiden (NL)
Leveraging in vitro dissolution profiles for prediction of in vivo human PK of oral IR formulations
15.05 – 15.30 Coffee break
15.30 – 15.55 Suruchi Bakshi, Certara QSP, Breda (NL)
Quantitative systems pharmacology modelling of complement system to study impact of novel therapies
15.55 – 16.20 Rick Admiraal, Princess Maxima Centre for Pediatric Oncology & University Medical Center, Utrecht (NL) & Leiden University, Leiden (NL)
From bench to bedside: Population pharmacokinetics, pharmacodynamics and prospective phase II study of individualized dosing for anti-thymocyte globulin in pediatric hematopoietic stem cell transplantation
16.20 – 16.45 Duc Pham, Leiden University, Leiden (NL)
Integrating time-kill data and population PK-PD to assess clinical probability of target attainment
16.45 – 17.10 Louis Sandra, Janssen Research & Development, Beerse (BE) & Ghent University, Ghent (BE)
Plasma and liver pharmacokinetics of the GalNAc-siRNA JNJ-73763989 in rAAV-HBV infected mice
17.10 – 18.00 Drinks