Topic: Advanced methods for treatment optimization
22 April 2024, Mgr. Sencie Instituut, Leuven, Belgium

12.00 – 13.00   Arrival, poster mounting, and lunch

13.00 – 13.10   Welcome by Erwin Dreesen (KU Leuven)

13.10 – 13.40   Keynote lecture Bram Verstockt & Erwin Dreesen (KU Leuven): From TDM to model-informed precision dosing of monoclonal antibodies in inflammatory bowel diseases

13.40 – 14.00   Jort Lokers (Erasmus MC, Rotterdam): Process Capability Indices from Lean Six Sigma as an Alternative and Multifaceted Metric for Target Attainment in Therapeutic Drug Monitoring

14.00 – 14.20   Kristof De Vos (KU Leuven): In vitro-in silico platform for mechanistic investigation of bile acid disposition in cultured hepatocytes

14.20 – 14.40   Zhiyuan Tan (Leiden University): Model-informed pazopanib dose optimization in real-world cancer patients

14.40 – 15.30    Coffee/tea break + recycle-your-poster session

15.30 – 15.50   Niclas Jonsson (Pharmetheus): Modeling covariates with large proportions of missing data: comparing the performance of the full random-effect model (FREM) and the full fixed-effects model (FFEM) approaches with different imputations schemes

15.50 – 16.10   Raphaëlle Lesage (ESQlabs): Treatment optimization with whole-body PBPK/QSP models: model behavior analysis and Shiny-app creation as workflow in PK-Sim and MoBi

16.10 – 16.30   Maud Hennion (PharmaLex): Benefit of Bayesian dynamic borrowing methods in evaluating the impact of newly developed oncology drugs on the standard-of-care

16.30 – 18.00   Drinks